Scientists have developed a groundbreaking technique for tattooing gold onto living tissue using a method called nanoimprint lithography. By printing living mouse embryo cells with patterns of gold nanodots and nanowires, researchers have taken a step towards integrating human cells with electronic devices. This technique could have significant health applications, allowing for the remote monitoring and control of individual cells in real-time. The ability to track the health of isolated cells could lead to early disease diagnosis and treatment. One of the main challenges in integrating electronics with human biology has been the incompatibility of living tissue with manufacturing techniques that use harsh chemicals, high temperatures, or vacuums. However, the new technique, which involves imprinting nanoscale patterns of gold onto living tissue, overcomes these obstacles. The researchers printed their nanoscale gold onto a silicon wafer coated in polymer, transferred it to thin films of glass, treated it with a biological compound, and coated it with a hydrogel before attaching it to fibroblast cells. The gold remained bonded to the cells for 16 hours without causing harm. This method opens up possibilities for developing more complex electronics, such as electrodes, antennas, and circuits, that can be integrated with living tissues and soft materials. The researchers believe that this nanopatterning process, combined with standard microfabrication techniques, could pave the way for the development of new cell culture substrates, biohybrid materials, bionic devices, and biosensors.
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