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Secrets Unveiled: Scientists Unlock Longevity Gene, Extending Human Lifespan!

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Secrets Unveiled: Scientists Unlock Longevity Gene, Extending Human Lifespan!
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Researchers at the University of Rochester have made a groundbreaking discovery by successfully transferring a longevity gene from naked mole rats to mice, resulting in improved health and a longer lifespan for the mice. Naked mole rats are known for their exceptional longevity and resistance to age-related diseases. The gene from naked mole rats produces high molecular weight hyaluronic acid (HMW-HA), which has potential anti-aging benefits. This discovery paves the way for potential advancements in improving human health and extending lifespan. The researchers genetically modified mice to produce the naked mole rat version of the gene, leading to enhanced cellular repair and protection, as well as a 4.4% increase in median lifespan. Naked mole rats have about ten times more HMW-HA in their bodies compared to mice and humans, which contributes to their resistance against diseases such as cancer. The study also found that the mice with the transferred gene had better protection against tumors and improved overall health. They also showed decreased inflammation, which is a hallmark of aging, and maintained a healthier gut as they aged. The researchers believe that HMW-HA’s ability to regulate the immune system directly contributes to its beneficial effects. The findings open up new avenues for exploring how HMW-HA can be used to improve lifespan and reduce inflammation-related diseases in humans. The researchers hope to accomplish this through either slowing down the degradation of HMW-HA or enhancing its synthesis. They have already identified molecules that slow down hyaluronan degradation and are testing them in pre-clinical trials. This study provides proof that longevity mechanisms unique to certain long-lived mammalian species can be transferred to benefit the lifespan and health of other species, including humans.

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